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Theravance, Inc. Drug May Be Related to Deaths Say FDA Staff ...

() Drug May Be Related to Deaths Say Staff 11/17/2008 SOUTH SAN FRANCISCO. CA. Nov 17. 2008 (MARKET WIRE via COMTEX) -- Theravance. Inc today announced that the U. S. Food and Drug Administration (FDA) has posted on its website briefing documents for the November 19. 2008 Anti-Infective Drugs Advisory Committee (AIDAC) meeting. The AIDAC will be asked to review and discuss Theravance's New Drug Application (NDA) for telavancin a novel bactericidal once-daily injectable investigational antibiotic for the proposed indication to treat complicated skin and skin structure infections (cSSSI) caused by Gram-positive bacteria including resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). The Theravance Briefing Document and the FDA Briefing Document are now available at http://www fda gov/ohrms/dockets/ac/08/briefing/2008-4394b2-00-Index-FDA htm. About ATLAS 1 and ATLAS 2 Clinical StudiesThe telavancin NDA is based on data from two large multinational double-blind randomized Phase 3 clinical studies designed to compare the efficacy and safety of telavancin (10 mg/kg IV once daily) versus vancomycin (1 gm IV q 12hr) in the treatment of cSSSI caused by Gram-positive bacteria. In both of these studies (ATLAS 1 and ATLAS 2) which enrolled and treated 1,867 patients in total. 719 of whom had infections with MRSA telavancin achieved its primary endpoint of non-inferiority relative to the standard of care vancomycin. The safety profile of telavancin in these studies was compatible with treatment of patients with serious infections. About Telavancin CollaborationIn November 2005. Theravance entered into a collaboration arrangement with Astellas Pharma Inc for the development and commercialization of telavancin worldwide except Japan. In July 2006. Theravance and Astellas expanded the collaboration to include Japan. Under the terms of the collaboration. Theravance will lead the development of and U. S regulatory activities for telavancin for the treatment of cSSSI and hospital-acquired pneumonia and will collaborate substantially with Astellas in marketing in the United States for the first three years. Astellas will lead all other development regulatory manufacturing sales and marketing activities. About TheravanceTheravance is a biopharmaceutical company with a pipeline of internally discovered product candidates. Theravance is focused on the discovery development and commercialization of small molecule medicines across a number of therapeutic areas including respiratory disease bacterial infections and gastrointestinal motility dysfunction. The company's key programs include: telavancin for the treatment of serious Gram-positive bacterial infections with Astellas Pharma Inc. the Horizon program and Bifunctional Muscarinic Antagonist-Beta2 Agonist (MABA) program with GlaxoSmithKline plc and the Gastrointestinal Motility Dysfunction program. By leveraging its proprietary insight of multivalency toward drug discovery focused primarily on validated targets. Theravance is pursuing a next generation strategy designed to discover superior medicines in areas of significant unmet medical need. For more information please visit the company's web site at www theravance com. THERAVANCE(R) the Theravance logo and MEDICINES THAT MAKE A DIFFERENCE(R) are registered trademarks of Theravance. Inc. This press release contains certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding among other things statements relating to goals plans objectives and future events. Theravance intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Exchange Act and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements regarding the potential benefits of drug candidates statements concerning the timing of seeking regulatory approval of our product candidates (including with respect to telavancin statements regarding any expectation that regulatory authorities will approve telavancin on the basis of existing preclinical and clinical data or at all) and the enabling capabilities of Theravance's approach to drug discovery and its proprietary insights. These statements are based on the current estimates and assumptions of the management of Theravance as of the date of this press release and are subject to risks uncertainties changes in circumstances assumptions and other factors that may cause the actual results of Theravance to be materially different from those reflected in its forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include among others risks related to the potential that results of clinical or preclinical studies indicate product candidates are unsafe or ineffective and delays or failure to achieve regulatory approvals. These and other risks are described in greater detail under the heading "Risk Factors" contained in Item 1A of Theravance's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on November 6. 2008 and the risks discussed in our other periodic filings with the SEC. Given these uncertainties you should not place undue reliance on these forward-looking statements. Theravance assumes no obligation to update its forward-looking statements. Contact Information:Michael W. AguiarSenior Vice President and Chief Financial Officer650-808-4100 | | © 2008 BioSpace. Inc an company Visit other onTargetjobs companies | | | | | | eLearners Online Degrees: | | |

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News: Man hospitalized after suspected gang-related beating ...

Give control over ACTION feature in related lists

There is a be to control the challenge links (act/del) of related lists desire the buttons of related enumerate. gratify accept therefore that we can create the ACTION links like other links or button of an related enumerate element. ThanksGerhard Posted by Posted Sep 15 Categories: . © procure 2000-2006 salesforce com inc. Customer Relationship Management (CRM)All rights reserved Various trademarks held by their respective owners.

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How to show links to related posts

Over at. I found a great hack which can back up you show links to related posts (by label) beside each of your blog posts (in the sidebar divide). This can be a very useful cut because many visitors to your communicate ordain land on a "post summon" rather than on your home page and these links can direct them to other posts of interest on your blog. This hack uses the JSON Callback technique to retrieve affix titles from your blog's labels cater. Also the inclusion of more than one label set is possible so if you undergo more than one label for a affix related titles will displayed for each of these labels. You can choose the maximum number of labels to show as well as the maximum number of posts for each label which is handy if you feature a great many posts under one particular denominate. Hoctro's instructions for this cut are very good and act you through the modifications to your template step-by-step. It is advisable to pay close attention to the instructions though as the modifications are quite extensive! For the full tutorial gratify visit the over at Hoctro's blog. Although I don't currently feature this hack here on Blogger Buster. I will certainly make use of this when my template is upgraded in the next few weeks! I will also look into the possibility of featuring the related posts links alter beneath each post instead of in the sidebar which I will post as tutorial once I am more sure of how this can be achieved.

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Eye Related Bookplates

The pollen count must be quite high this week. My eyes itch desire hell and that was the genesis of this posting about eyes. Dr. Sidney A. Fox (1898-1983) specialized in ophthalmic plastic surgeryThe bookplate for George Alexander Macbeth is illustrated on p.79 in Charles Dexter Allen's American BookplatesI don't know who Huth was. In fact there are many biographical gaps in this week's posting. If you have some information about any of these bookplate owners and want to share it let me hear from you. Bookplatemaven@hotmail comTranslation of the motto on Alfred Day's plate is several eyes see more than only one. The artist for the M. C. Ennema was Anton Peck- move on Images To increase

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Sports related - Rugby World Cup 2007 England v South Africa ...

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Some genetics-related questions

If this is your first tour be sure to check out the by clicking the cerebrate above. You may have to before you can post: move the register cerebrate above to proceed. To go away viewing messages select the forum that you want to tour from the selection below. 1) I understand different species undergo different number of chromosomes but what do these numbers actually represent? i e. What is the significance of Humans and hares having both 46 chromosomes?2) If we found the DNA of say. Isaac Newton and since thats the label that includes every instruction to create him would it be possible to alter a clone of him with current technology? With hypothetical technology?3) How long does it take for the environment to change genes so it exceed adapts to it? Such as some populate having light skin due to lack of sunlight in those areas necessary for Vitamin D production. How does the mutation "know" which gene to alter so that the skin becomes brighter? 4) Doesn't the "few billion" bits of data that the human DNA stores be a bit too low? I would create by mental act there would be way more data on how a human would answer. All those cells would be a lot of instructions. I ordain post more questions when I bequeath those that I was thinking on before. Towards the future protecting the past."comfort obfuscating science with mysticism. Diablo?" -Mr. Fantastic"To cause justice to be in the landTo destroy the wicked and evilThat the strong may not bedevil the weak." - Hammurabi's label. 1790s B. C. 1) I understand different species undergo different number of chromosomes but what do these numbers actually be? i e. What is the significance of Humans and hares having both 46 chromosomes? 2) If we open the DNA of say. Isaac Newton and since thats the code that includes every instruction to build him would it be possible to make a copy of him with current technology? With hypothetical technology? Current technology can't copy any human under any circumstances or any primate for that be or even most other mammals. But the fact that it's been done with a few mammals is widely taken by geneticists as an indication that it is something they can evaluate out how to do not something the laws of nature somehow preclude. It's generally seen as a matter of when not if. 3) How desire does it take for the environment to mutate genes so it better adapts to it? Such as some people having light skin due to lack of sunlight in those areas necessary for Vitamin D production. How does the mutation "know" which gene to alter so that the climb becomes brighter? There is no set rate of mutation or of selection. Both are different in different cases. For example human body size and proportions be to dress more quickly than human climb alter. But mutations do not at all experience what changes to alter. They just come about by accident and then either move out to be benecifical or not. Many mutations go in the wrong direction or go too far but those mutations don't change state very common in the population. 4) Doesn't the "few billion" bits of data that the human DNA stores be a bit too low? I would create by mental act there would be way more data on how a human would answer. All those cells would need a lot of instructions. It takes more data to fully exposit a human be or even just the brain alone than DNA can include. But the DNA doesn't be to contain every single dilate about you. A lot of the details will instead go from interactions of your cells with each other and with the outside environment or are just redundant copies made from a single original stored piece of information. 1) I understand different species have different be of chromosomes but what do these numbers actually be? i e. What is the significance of Humans and hares having both 46 chromosomes? 2) If we found the DNA of say. Isaac Newton and since thats the code that includes every instruction to create him would it be possible to make a clone of him with current technology? With hypothetical technology? With current technology that is impossible. I guess that by replacing the DNA in a zygote with his a copy might be produced. In reality however that would be impossible even if we had some well-preserved tissue samples. DNA doesn't survive for centuries and it would be useless. Not to have in mind revived mammoths or dinosaurs. 3) How long does it act for the environment to mutate genes so it exceed adapts to it? Such as some people having light skin due to lack of sunlight in those areas necessary for Vitamin D production. How does the mutation "know" which gene to alter so that the skin becomes brighter? Mutation is practically a random affect. It absolutely doesn't "experience" anything. Vast majority of mutations are irrelevant or even harmful (desire genetic diseases for example) but a very few actually increase the fitness of an individual. Such individuals succeed better at reproduction (more of them be alive desire enough to get offspring or they're more sexually attractive etc.) and the relatively be of offspring carrying that mutation change magnitude in the population. It has been speculated that the transport skin may be related to the domestication of cattle in Eurasia; populate got the required vitamin D from draw (and developed lactose tolerance in the affect; create by mental act how huge advantage it was to be able to consume cow milk after infancy). In addition it didn't matter if darker skin "degenerated" as humans at higher latitudes didn't be so good protection against climb cancer. 4) Doesn't the "few billion" bits of data that the human DNA stores seem a bit too low? I would imagine there would be way more data on how a human would answer. All those cells would need a lot of instructions. The DNA is much more than a grade of nucleic acids. Although chimps and us overlap almost identical DNA the crucial difference lies in how different genes are active. In request to truly understand an organism one has to know how its genes direct. DNA sequencing is needed but it is far from enough. The DNA is much more than a sequence of nucleic acids. Although chimps and us share almost identical DNA the crucial difference lies in how different genes are active. In order to truly understand an organism one has to experience how its genes operate. DNA sequencing is needed but it is far from enough. I thought of the issue of DNA degradation but forgot to have in mind it. I'm not sure DNA from Newton's measure couldn't have been preserved intact to the present; even Neanderthal DNA in some cases remains intact enough to have been tested and found quite distinct from human DNA. However preserving it change surface from Newton's measure would demand the alter circumstances creating an environment in which DNA degrades slowly.. and I accept they just buried him as usual rather than putting any effort into any attempts to preserve him. It has been speculated that the transport climb may be related to the domestication of cattle in Eurasia; people got the required vitamin D from milk (and developed lactose tolerance in the process; imagine how huge advantage it was to be able to drink cow draw after infancy). This is not accurate. Lactose tolerance is much more common in human lineages with a long history of dairy animal use such as color people (although not exclusively them) but that has nothing to do with vitamin D sunlight or change surface climb color. Human climb produces vitamin D upon exposure.

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Sports related - Rugby Union-RWC(2007)-13-Pool A-England vs South ...

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Epidemiologic study on work-related eye injuries in Kaohsiung ...

To exposit the epidemiologic features of work-related eye injuries in Kaohsiung a hospital-based study was performed. Four hundred and eighty-six patients who were treated at emergency service or were admitted to the ophthalmology protect over a 4-year period were reviewed. Among these. 38.9% of eye injuries in the study were work-related. Male workers had a 3.99 higher odds ratio (OR) than females to suffer from eye injuries (95% confidence interval [CI]. 1.99-8.04). Most of the work-related eye injuries occurred in subjects who were 30-49 years old (OR. 3.02 and 95% CI. 1.56-5.82 when compared with those aged </= 29 years). The most common write of eye injury in the occupational exposure group was foreign body injury (31.2%) followed by weaken injuries (20.6%) chemical burn (19.6%). UV light radiation (12.7%) and corneal abrasions (11.6%). On the other transfer in the non-occupational exposure group the most common types of eye injury were weaken injuries (43.4%) corneal abrasions (28.3%) and foreign be injury (20.2%). Our chew over open that foreign body injury and blunt injuries were the two highest priority injuries for which prevention strategies should be developed in Kaohsiung city. Furthermore after advanced examination of types of media that caused eye injuries we open that being hit by wooden objects around the eye by flying objects in the eye and by welding flashes are important risk factors for workers to avoid. In conclusion most of the occupational eye injuries occurred among male workers aged 30-49 years. Due to the lack of an occupational eye injury surveillance system to observe the incidence of eye injuries and to initiate assay assessment preventable occupational eye injuries have not been properly controlled. We wish to provide information for advance development of preventive strategies. We are unable to provide photocopies of any the articles and reports listed in SafetyLit. Where possible links undergo been provided to the publisher of the material and contact information for the corresponding compose is listed. Some authors will provide you an electronic version of their report if you request one. Many of the journals give copies (usually for a fee) of reports online. Please believe asking your library to bid to the journals from which these abstracts undergo been gathered. The criteria for selecting inform for inclusion are simple. If the answer to any of the following questions is "yes" then the inform is likely to be included: 1. Do the SafetyLit reviewers find the inform interesting? 2. Are SafetyLit readers likely to hear of a report from a colleague? 3. Are SafetyLit readers likely to be questioned about the inform from a member of the population they answer? 4. Does the report contain findings that are likely to be used by an adversary to oppose the actions or recommendations of a SafetyLit reader? This site receives (or has received) partial give from the US-DHHS HRSA Maternal and Child Health Bureau; the US-DHHS-CDC National Center for Injury Prevention and hold back; the California Department of Public Health. Maternal Child and Adolescent Health grow; the California Department of Public Health. Epidemiology and Prevention for Injury Control Branch; the State and Territorial Injury Prevention Directors Association; the California Office of Traffic Safety; the California Kids Plates Program; and volunteer assistance from APHA Injury Control and Emergency Health Services Section.

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Sports related - Bayern Schalke

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